Microstructural remodeling in the post-infarct porcine heart measured by diffusion tensor MRI and T1-weighted late gadolinium enhancement MRI

نویسندگان

  • Geoffrey L Kung
  • Olujimi Ajijola
  • Rafael J Ramirez
  • Jin Kyu Gahm
  • Wei Zhou
  • N Wisniewski
  • Aman Mahajan
  • Alan Garfinkel
  • Kalyaman Shivkumar
  • Daniel Ennis
چکیده

The objective of this study was to quantify microstructural remodeling in peri-infarcted and infarcted porcine myocardium using diffusion tensor MRI (DT-MRI) for the first time. High resolution ex vivo late gadolinium enhanced (LGE) MRI was used to segment the DT-MRI data into normal, peri-infarct and infarcted myocardium. LGE-MRI based segmentation produces regions with significantly different microstructural remodeling.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction

BACKGROUND Knowledge of the three-dimensional (3D) infarct structure and fiber orientation remodeling is essential for complete understanding of infarct pathophysiology and post-infarction electromechanical functioning of the heart. Accurate imaging of infarct microstructure necessitates imaging techniques that produce high image spatial resolution and high signal-to-noise ratio (SNR). The aim ...

متن کامل

Serial diffusion tensor MRI and tractography of the mouse heart in-vivo: impact of ischemia on myocardial microstructure

Background Diffusion tensor MRI (DTI) has been used to investigate infarct healing and remodeling in several species. Tractography of the myocardium has also recently been reported. However, these prior studies were conducted ex-vivo on excised hearts. Here, we use in-vivo DTI of the mouse heart to follow microstructural changes in the myocardium in response to ischemia. Mean diffusivity (MD) a...

متن کامل

Inflammatory response after ischemic stroke: a USPIO-enhanced MRI study in patients.

BACKGROUND AND PURPOSE The intensity of the inflammatory response may be related to the volume of acute infarction. Ultra-small superparamagnetic particles of iron oxide (USPIO) may enable assessment of neuroinflammation. We aimed to assess whether the intensity of the inflammatory response might be related to the subacute ischemic lesion volume. METHODS We enrolled patients who presented wit...

متن کامل

Myocardial infarct delineation in vivo using diffusion tensor MRI and the tractographic propagation angle

Background Delayed gadolinium enhancement (Gd-DE) is widely used to detect scar formation following myocardial infarction (MI) [1], but cannot be performed in patients with renal impairment. Here we use the tractographic propagation angle (PA), a novel index derived from 3D diffusion tensor MRI (DTI), to detect changes in myocardial fiber architecture post-MI [2]. We compare image segmentation ...

متن کامل

Size of myocardial fibrosis by LGE, pre- and post-contrast T1 and ECV in patients with hypertrophic cardiomyopathy referenced to normal appearing myocardium or healthy volunteers

Background Myocardial fibrosis is associated with abnormal cardiac remodeling and poor prognosis in patients with hypertrophic cardiomyopathy. Currently, new cardiac MRI (CMR) techniques such as T1-mapping and extracellular volume (ECV) measurement are available to quantify diffuse myocardial fibrosis. We analyzed the size of myocardial fibrosis using preand post-contrast T1, ECV and late gadol...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2012